Pyrrolo[2,3-b]pyridine derivatives active as kinase...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07728140

ABSTRACT:
Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

REFERENCES:
patent: 3320268 (1967-05-01), Shen et al.
patent: 5468757 (1995-11-01), Jakubowski et al.
patent: 6476034 (2002-11-01), Wang et al.
patent: 6632819 (2003-10-01), Wang et al.
patent: WO 95/28400 (1995-10-01), None
patent: WO 96/11929 (1996-04-01), None
patent: WO 97/03069 (1997-01-01), None
patent: WO 98/50364 (1998-11-01), None
patent: WO 99/32111 (1999-07-01), None
patent: WO 99/37637 (1999-07-01), None
patent: WO 99/58496 (1999-11-01), None
patent: WO 00/21950 (2000-04-01), None
patent: WO 00/21951 (2000-04-01), None
patent: WO 00/24717 (2000-05-01), None
patent: WO 00/71537 (2000-11-01), None
patent: WO 01/01986 (2001-01-01), None
patent: WO 01/58869 (2001-08-01), None
patent: WO 01/98299 (2001-12-01), None
patent: WO 03/082868 (2003-10-01), None
McGraw-Hill Dictionary of Chemical Terms(1990)p. 282.
Concise Encyclopedia Chemistry (1993),p. 490.
Hawley's Condensed Chemical Dictionary (1993)p. 594.
Wolff, Manfred E. “Burger's Medicinal Chemistry, 5ed, Part I”, John Wiley & Sons, 1995, pp. 975-977.
Banker, G.S. et al, “Modern Pharmaceutics, 3ed.”, Marcel Dekker, New York, 1996, pp. 451 and 596.
Fivush A.M. et al., “AMEBA: An Acid Sensitive Aldehyde Resin for Solid Phase Synthesis”,Tetrahedron Letters38(41):7151-7154 (1997).
Jensen K.J. et al., “Backbone Amide Linker (BAL) Strategy for Solid-Phase Synthesis of C-Terminal-Modified and Cyclic Peptides”,J. Am. Chem. Soc.120(22):5441-5452 (1998).
Alsina J. et al., “Solid-Phase Synthesis with Tris(alkoxy)benzyl Backbone Amide Linkage (BAL)”,Chem. Eur. J.5(10):2787-2795 (1999).
Palmer B.D. et al., “Structure-Activity Relationships for 5-Substituted 1-Phenylbenzimidazoles as Selective Inhibitors of the Platelet-Derived Growth Factor Receptor”,J. Med. Chem. 42(13):2373-2382 (1999).
Lackey K. et al., “The Discovery of Potent cRaf1 Kinase Inhibitors”,Bioorganic&Medicinal Chemistry Letters10:223-226 (2000).
Cohen P., “The Development and Therapeutic Potential of Protein Kinase Inhibitors”,Current Opinion in Chemical Biology3:459-465 (1999).
Hosoi T. et al., “Evidence for Cdk5 as a Major Activity Phosphorylating Tau Protein in Porcine Brain Extract”,J. Biochem.117(4):741-749 (1995).
Schneller S.W. et al., “Synthesis of 4-Amino-1H-Pyrrolo[2,3-b]Pyridine (1,7-Dideazaadenine) and 1H-Pyrrolo[2,3-b]Pyridin-4-ol (1,7-Dideazahypoxanthine)”,Journal of Organic Chemistry45(20):4045-4048 (1980), Chemical Abstracts C.A. 93:168162.
Huang X. et al., “Expanding Pd-Catalyzed C-N Bond-Forming Processes: The First Amidation of Aryl Sulfonates, Aqueous Amination, and Complementarity with Cu-Catalyzed Reactions”,J. Am. Chem. Soc.125(22):6653-6655 (2003).
Ali M.H. et al., “An Improved Method for the Palladium-Catalyzed Amination of Aryl Iodides”,J. Org. Chem.66(8):2560-2565 (2001).
Kuwano R. et al., “Aqueous Hydroxide as a Base for Palladium-Catalyzed Amination of Aryl Chlorides and Bromides”,J. Org. Chem.67(18):6479-6486 (2002).
Mouaddib A. et al., “Synthesis of Benzo[5′,6′]Cyclohepta[4,5]pyrrolo[2,3-b]Pyridine-12-One”,Tetrahedron Letters40:5853-5854 (1999).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Pyrrolo[2,3-b]pyridine derivatives active as kinase... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrrolo[2,3-b]pyridine derivatives active as kinase..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrrolo[2,3-b]pyridine derivatives active as kinase... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4247956

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.