Pyrrolo[2,3-b]indole-ketones and analogs

Details Pyrrolo[2,3-b]indole-ketones and analogs Pyrrolo[2,3-b]indole-ketones and analogs

1991-09-26

1993-06-01

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548429, C07D48704, A61K 3140

Patent

active

052160173

ABSTRACT:
This invention relates to pyrrolo[2,3-b]indole ketones of the formula ##STR1## where R.sub.1 is loweralkyl, aryl or arylloweralkyl; R.sub.2 is hydrogen, halogen or loweralkyl; R.sub.3 is hydrogen or loweralkyl; R.sub.4 is loweralkyl or arylloweralkyl; R.sub.5 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, arylloweralkyl, formyl, loweralkylcarbonyl, arylloweralkylcarbonyl or loweralkoxycarbonyl; Y is hydrogen, loweralkyl or loweralkoxy; the pharmaceutically acceptable addition salts thereof, and where applicable, the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention are useful in the treatment of memory impairment characterized by a cholinergic deficit such as that associated with electroshock-induced amnesia and Alzheimer's disease and other senile dementia.

REFERENCES:
patent: 4791107 (1988-12-01), Hamer
patent: 4971992 (1990-11-01), Glamkowski
Julian, J.A.C.S. 57, 563, 755 (1935).
Tamguchi, Chem. Pharm. Bull 31 (6) 1856 (1963).
Kosugi, Chem. Letters 1982, 939-940.

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