Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-08-14
2009-10-27
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S496000
Reexamination Certificate
active
07608615
ABSTRACT:
The present invention provides quinazolinone linked pyrrolo[2,1-c][1,4]benzodiazepine hybrid of general formula 5,wherein, R is alkyl or halo group selected from H, Cl, F or CH3and n=1 to 3 useful for antitumour/anticancer activity. The present invention also provides a process for the preparation of quinazolinone linked pyrrolo[2,1-c][1,4]benzodiazepine hybrid general formula 5.
REFERENCES:
Gregson et al., “Design, synthesis and evaluation of a novel pyrrolobenzodiaepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity”,J Med Chem(2001) 44:737.
Hurley et al., “Pyrrolo(1,4) benzodiazepine antitumor antibiotics. In vitro interaction of anthramycin, sibiromycin and tomaymycin with DNA using specifically radiolabelled molecules”,Biochem Biophys Acta(1977) 475:521.
Kamal et al., “Design, synthesis and evaluation of new noncross-linking pyrrolobenzodiazepine dimers with efficient DNA binding ability and potent antitumor activity,”J Med Chem(2002) 45:4679.
Kamal et al., “A new route to 4-phnyl-2(1H) quinazolinones; reactions of 2-amino benzophenones with chlorosulfonyl isocyanate”,Syn Commun(1980) 10:799-804.
Kaplan and Hurley, “Anthramycin binding to deoxyribonucleic acid-mitomycin C complexes. Evidence for drug-induced deoxyribonucleic acid conformational change and cooperativity in mitomycin C binding”,Biochemistry(1981) 20:7572.
Kunimoto et al. “Mazethramycin, a new member of anthramycin group antibiotics”,J Antibiot(1980) 33:665.
Thurston et al., “Synthesis of a novel GC-specific covalent-binding DNA affinity-cleavage agent based on pyrrolobenzodiazepines (PBDs),”Chem Commun(1996) 563-565.
Thurston et al., “Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-c] [1,4] benzodiazepine DNA Interstrand Cross-Linking Agents”,J Org Chem(1996) 61:8141.
Adhi Venkata Ramana
Ahmed Kamal
Ankati Hari Babu
Council of Scientific & Industrial Research
DLA Piper (LLP) US
Kifle Bruck
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