Pyrrolo [2,1-c][1,4]benzodiazepine-anthraquinone conjugates...

Details Pyrrolo [2,1-c][1,4]benzodiazepine-anthraquinone conjugates... Pyrrolo [2,1-c][1,4]benzodiazepine-anthraquinone conjugates...

2007-02-06

2007-02-06

Kifle, Bruck (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S496000

Reexamination Certificate

active

11024240

ABSTRACT:
The present invention relates to synthesis of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone hybrids (V) wherein n=3,4; R=H, OHand to their use as antitumour agents.

REFERENCES:
Kunimoto, S., et al., “Mazethramycin, A New Member of Anthramycin Group Antibiotics”, The Journal of Antibiotics, Jun. 1980, pp. 665-667.
Thurston, D.E., et al., “Synthesis of a Novel GC-Specific Covalent-Binding DNA Affinity-Cleavage Agent Based on Pyrrolobenzodiazepines (PDBs)”, Chemical Communications, 1996, pp. 563-565.
Monks, A., et al., “Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines”, Journal of the National Cancer Institute, Jun. 5, 1991, vol. 83, No. 11, pp. 757-766.
Damayanthi, Y., et al., “Design and Synthesis of Novel Pyrrolo[2,1-c][1,4]benzodiazepine-Lexitropsin Conjugates”, Journal of Organic Chemistry, Jan. 8, 1999, vol. 64, No. 1, pp. 42290-42292.
Hurley, L.H., et al., “Pyrrolo(1,4)benzodiazepine Antitumor Antibiotics In Vitro Interaction of Anthramycin, Sibiromycin and Tomaymycin With DNA Using Specifically Radiolabelled Molecules”, Biochemica et Biophysica Acta, Apr. 4, 1977, vol. 475, No. 3, pp. 521-535.
Kamal, A., et al., “Design and Synthesis of C-8 Linked Pyrrolobenzodiazepine-Naphthalimide Hybrids as Anti-Tumour Agents”, Bioorganic & Medicinal Chemistry Letters, 2002, vol. 12, pp. 1933-1935.
Kamal, A., et al., “Design, Synthesis, and Evaluation of New Noncross-Linking Pyrrolobenzodiazepine Dimers with Efficient DNA Binding Ability and Potent Antitumor Activity,” Journal of Medicinal Chemistry, Oct. 10, 2002, vol. 45, No. 21, pp. 4679-4688.
Kaplan, D.J., et al., “Anthramycin Binding to Deoxyribonucleic Acid-Mitomycin C Complexes. Evidence for Drug-Induced Deoxyribonucleic Acid Conformational Change and Cooperativity in Mitomycin C Binding,” Biochemistry, Dec. 22, 1981, vol. 20, No. 26, pp. 7572-7580.
Collier, D.A., et al., “Synthesis, Molecular Modeling, DNA Binding, and Antitumor Properties of Some Substituted Amidoanthraquinones,” Journal of Medicinal Chemistry, Apr. 1988, vol. 31, No. 4, pp. 847-857.
Thurston, D.E., et al., “O-Debenzylation of a Pyrrolo[2,1-c][1,4]benzodiazepine in the Presence of a Carbinolamine Functionality: Synthesis of DC-81,” Synthesis, Jan. 1990, No. 1, pp. 81-84.
Kamal, A. et al., “Pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates. Synthesis, DNA binding and cytotoxity,” Bioorganic & Medicinal Chemistry Letters 2004, vol. 14, pp. 4907-4909.
Kohn K.W. et al., C. L. J. Mol. Biol. 1970, vol. 91, p. 551.
Gregson, S.J. et al., J. Med. Chem. 2001, vol. 44, p. 737.

Affiliated with

Also associated with

Rating

Pyrrolo [2,1-c][1,4]benzodiazepine-anthraquinone conjugates... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrrolo [2,1-c][1,4]benzodiazepine-anthraquinone conjugates..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrrolo [2,1-c][1,4]benzodiazepine-anthraquinone conjugates... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3822705