Pyrrolo[2,1-b] [3]benzazepines useful for producing a skeletal m

Details Pyrrolo[2,1-b] [3]benzazepines useful for producing a skeletal m Pyrrolo[2,1-b] [3]benzazepines useful for producing a skeletal m

1977-06-06

1978-09-05

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

542471, 544142, 26032631, 26029361, 2603265B, 2603269, 2603265S, 26032662, 424267, 42424856, C07D48704, A61K 3140

Patent

active

041121120

ABSTRACT:
11-Aminopropylidene-Pyrrolo[2,1-b] [3]benzazepines are disclosed to have pharmaceutical utility as skeletal muscle relaxants and tranquilizers. They are prepared by a Grignard reaction on pyrrolo[2,1-b] [3]benzazapin-11-ones followed by dehydration, or by a Wittig reaction on the same ketones.

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patent: 4075225 (1978-02-01), Rokach et al.
Huigsen et al., Chem. Ber., 93, 65-81 (1960).
Weinstein et al., J. Org. Chem., 41, No. 5, 875-878 (1976).

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