Pyrrolo[1,2-b][1,2,5]triazepines and pharmaceutical compositions

Details Pyrrolo[1,2-b][1,2,5]triazepines and pharmaceutical compositions Pyrrolo[1,2-b][1,2,5]triazepines and pharmaceutical compositions

1984-07-02

1985-05-14

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

2602393B, 548557, 548465, 544372, A61K 3155, C07D25502, C07D25504

Patent

active

045171955

ABSTRACT:
There are described novel pyrrolo[1,2-b][1,2,5]triazepines of the general formula ##STR1## where R is hydrogen, loweralkyl, loweralkylaminoloweralkyl or diloweralkylaminoloweralkyl; X is hydrogen, halogen (fluorine, chlorine, bromine or iodine), trifluoromethyl or nitro; and Y is hydrogen, halogen or loweralkyl. Also described are derivatives of 1-amino-2-benzoylpyrrole having the general formula ##STR2## where R, X and Y are as defined above, and R.sub.1 is hydrogen, ##STR3## Compounds I and II are useful as analgesic, anxiolytic and/or anticonvulsant agents, and many of Compounds II are useful as intermediates for synthesizing Compounds I.

REFERENCES:
patent: 3121081 (1964-02-01), Dickinson
patent: 4022766 (1977-05-01), Fontanella et al.
patent: 4201712 (1980-05-01), Weber et al.
patent: 4402970 (1983-09-01), Mariani et al.
Essassi et al. "J. Het. Chem." vol. 20, pp. 1015-1018 (1983) French along with partial English Translation.
Flitsch et al. "Chem. Ber." vol. 102, pp. 3268-3276 (1967).
Dickinson et al. "J. Org. Chem." vol. 27, No. 7, pp. 2470-2473 (1962).
Fontenella et al. "European J. Med. Chem."-Chimica Therapentica vol. 11, No. 3, pp. 217-220 (1976).

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