Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-03-07
1993-03-02
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540496, 540560, A61K 3155, C07D47514
Patent
active
051909391
ABSTRACT:
The invention relates to compounds of general formula I: ##STR1## in which: R.sub.1 represents a radical of general formula (Z.sub.0), (Z.sub.1), (Z.sub.2), (Z.sub.3) or (Z.sub.4) ##STR2## R.sub.2 represents a methylene radical, a hydroxymethylene radical, a carbonyl radical or a radical of general formula (Y.sub.1), (Y.sub.2), (Y.sub.3) or (Y.sub.4): ##STR3## or, with R.sub.12 and the nitrogen atom to which they are attached, forms a radical of general formula (W): ##STR4## R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12 and n being as defined in the description, medicinal products containing the same and a method-of-treating metabolic ailments therewith.
REFERENCES:
Novel Convenient Synthesis of 1,4-Diazepines, 6-Alkoxy-5,6-Dihydro-4H-Pyrrolo [1,2-a] Thieno [3,2-f]-1,4-Diazepine-4-ones, S. Rault et al., Heterocycles (1979) 12 (8) pp. 1009-1011.
Pyrrolo [1,2-a] Thieno [3,2-f]-1,4-Diazepines. Novel Synthesis and X-Ray Analysis, S. Rault, et al., Tetrahedron Letters (1979)N.degree. 7 pp. 643-644.
Synthesis of 4H-Pyrrolo [1,2-a] Thieno [3,2-f] [1,4] Diazepines, H. Fujimori, et al., Journal of Heterocyclic Chemistry (1977) 14 (2) pp. 235-240.
Synthese et etude de la 4H-Dihydro-5,6 Pyrrolo [1,2-a] Thieno [3,2-f] Diazepine-1,4, Comptes rendus de l'Academie des Science de Paris (1978) 287 pp. 117-120.
Boulouard Michel
Dallemagne Patrick
Devissaguet Michelle
Guardiola Beatrice
Rault Sylvain
Adir et Compagnie
Bond Robert T.
Hueschen Gordon W.
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