Pyrrolo[1,2- a ] pyrazin-1(2H)-one and pyrrolo[1,2- d...

Details Pyrrolo[1,2- a ] pyrazin-1(2H)-one and pyrrolo[1,2- d... Pyrrolo[1,2- a ] pyrazin-1(2H)-one and pyrrolo[1,2- d...

2007-05-29

2010-11-16

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S350000

Reexamination Certificate

active

07834015

ABSTRACT:
The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.

REFERENCES:
patent: 2008/0161292 (2008-07-01), Giranda et al.
patent: WO02/36576 (2002-05-01), None
patent: WO02/090334 (2002-11-01), None
patent: WO03/093261 (2003-11-01), None
patent: WO2004/080976 (2004-09-01), None
patent: WO2006/021801 (2006-03-01), None
patent: WO2008/017883 (2008-02-01), None
patent: WO2008/072779 (2008-06-01), None
Jagtap, et al, Nature Reviews Drug Discovery, vol. 4, p. 421 (2005).
Bryant, et al, Nature, vol. 434, pp. 913-917 (2005).
Peukert, et al, Exp. Opin. Ther. Patents, vol. 14, No. 11, p. 1531 (2004).

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