Pyrrolo[1,2-A]imidazoledione effective in the treatment of...

Details Pyrrolo[1,2-A]imidazoledione effective in the treatment of... Pyrrolo[1,2-A]imidazoledione effective in the treatment of...

2011-07-05

2011-07-05

Shameem, Golam M (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S301700, C548S302700, C514S385000, C514S386000

Reexamination Certificate

active

07973066

ABSTRACT:
The use of a compound of formula (I), is disclosed in treating and/or preventing 5 chemotherapy-induced peripheral neurotoxicity (CIPN). The invention includes pharmaceutical compositions wherein the compound of formula (I) is present in a mixture with anticancer agents. An improved anticancer treatment with reduced CIPN-related side effects is also provided.

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patent: W02004085438 (2004-10-01), None
Robert Cavaliere, MD. et al, “Neurologic Toxicities of Cancer Therapies”, Current Neurology and Neuroscience Reports 2006, 6:218-226.
International Search Report of PCT/EP2007/062323 dated Jul. 2, 2008.
Frederick H. Hausheer et al.; “Diagnosis, Management, and Evaluation of Chemotherapy-Induced Peripheral Neuropathy”; Seminars in Oncology; vol. 33, No. 1, Feb. 2006; pp. 15-49.
Mark Stillman MD and Juan P. Cata, MD; “Management of Chemotherapy-induced Peripheral Neuropathy”; Current Pain and Headache Reports 2006; vol. 10, No. 4, Aug. 2006; pp. 279-287.
Guido Cavaletti and Paola Marmiroli; “Chemotherapy-induced peripheral neurotoxicity”; Expert Opinion on Drug Safety Nov. 2004; vol. 3, No. 6, Nov. 2004; pp. 535-546.
Sarah J.L. Flatters, Gary J. Bennett; “Ethosuximide reverses paclitaxel-and vincristine-induced painful peripheral neuropathy”; Pain 109; 2004; pp. 150-161.
Stefan Quasthoff, Hans Peter Hartung; “Chemotherapy-induced peripheral neuropathy”; J Neurol (2002); pp. 9-17.

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