Pyrrolo[1,2-a] [4,1]benzoxazepine derivatives useful as calmodul

Details Pyrrolo[1,2-a] [4,1]benzoxazepine derivatives useful as calmodul Pyrrolo[1,2-a] [4,1]benzoxazepine derivatives useful as calmodul

1986-01-21

1988-07-19

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540543, 540547, A61K 3155, C07D41306, C07D41314, C07D49804

Patent

active

047585595

ABSTRACT:
Disclosed are the compounds of the formula ##STR1## wherein n represents the integer 1,2,3 or 4; R.sub.1 represents hydrogen, lower alkyl, halogen, trifluoromethyl, hydroxy or lower alkoxy; R.sub.2 represents hydrogen or lower alkyl; R.sub.3 represents hydrogen, lower alkyl or halogen; R.sub.4 represents amino, lower alkylamino, di-lower alkylamino, morpholino, N-lower alkyl or N-aryl piperazino, pyrrolidino, piperidino or substituted piperidino selected from ##STR2## in which R.sub.5 represents hydrogen, halogen or lower alkyl; and pharmaceutically acceptable salts thereof; which are useful in mammals as calmodulin antagonists for the treatments of gastrointestinal disorders.

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