Pyrrolizine compounds useful as anti-inflammatory agents

Details Pyrrolizine compounds useful as anti-inflammatory agents Pyrrolizine compounds useful as anti-inflammatory agents

2008-05-20

2008-05-20

Anderson, Rebecca (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S413000

Reexamination Certificate

active

07375237

ABSTRACT:
Pyrrolizine compounds having the formula (I),or pharmaceutically-acceptable salts thereof, are effective in treating inflammatory or immune diseases, where A is a four- to seven-membered saturated ring, K is O or S, and R1, R2, R3n, and M are defined in the specification.

REFERENCES:
patent: 5683965 (1997-11-01), Bachmann et al.
patent: 0 442 077 (1995-11-01), None
patent: 2000-293276 (2000-09-01), None
patent: WO 98/39303 (1998-09-01), None
patent: WO 99/20617 (1999-04-01), None
patent: WO 99/20618 (1999-04-01), None
patent: WO 99/49856 (1999-10-01), None
patent: WO 00/21920 (2000-04-01), None
patent: WO 03/029245 (2003-04-01), None
Dodd et al., “Design of LFA-1 antagonists based on a 2,3-dihydro-1h-pyrrolizin-5(1aH)-one scaffold”, Bioorg. Med Chem Lett, 17, 2007, 1908-1911.
Giblin et al., “LFA-1 as a Key regulator of immune function: approaches toward the development of LFA-1 based therapeutics”, current pharm design, 2006, 12, 2771-2795.
Barnes, P.J.; “Mediators of Chronic Obstructive Pulmonary Disease”, Pharmacol. Rev. (2004), vol. 56, p. 515-548.
Parlier et al., Organometallics, 14, 1995, 2761.
http://www.health.harvard.edu/special—health—reports/Chronic—Obstructive—Pulmonary—Disease.htm.
http://www.mayoclinic.com/health/alzheimers-disease/DS00161/DSECTION=3.
http://www.medindia.net/patients/patientinfo/Alzheimers—treatment.htm.
FACT Sheet , Alzheimers association (2 pages).
http://www.icos.com/popUps/pop—ic747.html.
Parlier, A. et al., “Reaction of Aminocarbene Complexes of Chromium with Alkynes. 5. Influence of the Ring Size on the Product Distribution. Formation of Pyrroles from Pyrrolidine and Its Derivative-Substituted Carbene Complexes”, Organometallics, vol. 14, No. 6, pp. 2760-2774 (1995).
Rudler, H. et al., “Unexpected ring opening of cycloaminocarbene complexes of chromium upon alkyne insertion reactions”, Journal of Organometallic Chemistry, vol. 358, pp. 245-272 (1988).
Anderson, D.C. et al., “Leukocyte LFA-1, OKM1, p150,95 deficiency syndrome: functional and biosynthetic studies of three kindreds”, Federation Proceedings, vol. 44, No. 10, pp. 2671-2677 (1985).
Diamond, M.S. et al., “The dynamic regulation of integrin adhesiveness”, Current Biology, vol. 4, No. 6, pp. 506-517 (1994).
Górski, A., “The roll of cell adhesion molecules in immunopathology”, Immunology Today, vol. 15, No. 6, pp. 251-255 (1994).
Sanfilippo, P.J. et al., “Novel Thiazole Based Heterocycles as Inhibitors of LFA-1/ICAM-1 Mediated Cell Adhesion”, J. Med. Chem., vol. 38, No. 7, pp. 1057-1059 (1995).

Affiliated with

Also associated with

Rating

Pyrrolizine compounds useful as anti-inflammatory agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrrolizine compounds useful as anti-inflammatory agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrrolizine compounds useful as anti-inflammatory agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2762677