Pyrrolizidine derivative and pharmaceutical composition thereof

Details Pyrrolizidine derivative and pharmaceutical composition thereof Pyrrolizidine derivative and pharmaceutical composition thereof

1985-02-21

1988-06-14

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548453, A61K 3140, C07D48706

Patent

active

047512326

ABSTRACT:
A novel pyrrolizidine derivative of the formula, ##STR1## which has potent antiarrhythmic activity and low toxicity is produced. The derivative can be synthesized: by acylating 2,6-xylidine to protect the amino group, nitrating the protected xylidine to introduce a nitro group at 3-position, reducing the nitro group to an amino group, followed by diazotizing and hydrolyzing, and then the resulted 3-hydroxy-2,6-dimethylaniline being condensed with 8-halocarbonylmethylpyrrolizidine; or by nitrating N-(2',6'-dimethyl)phenyl-8-pyrrolizidineacetamide to introduce a nitro group at 3'-position, reducing the nitro group to amino group, diazotizing the amino group and hydrolyzing the diazonium compound.

REFERENCES:
patent: 4213983 (1980-07-01), Hadley et al.
patent: 4564624 (1986-01-01), Miyano et al.

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