Pyrrolinone-based compounds

Details Pyrrolinone-based compounds Pyrrolinone-based compounds

1993-02-17

1996-02-06

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544141, C07D20700, C07D41300

Patent

active

054896924

ABSTRACT:
Novel pyrrolinone-based compounds mimic or inhibit the biological and/or chemical activity of peptides, including peptide .beta.-strand conformations. Certain compounds contain functionalized pyrrolinone units in place of one or more amino acids of a target peptide.

REFERENCES:
patent: 4885292 (1989-12-01), Ryono et al.
patent: 5075302 (1991-12-01), Neustadt et al.
Smith, III Amos B III JACS 1992, 114 10672-10674.
Karady et al., Enantioretentive Alkylation of Acyclic Amino Acids, Tetrahedron Letters, vol. 25, No. 39, pp. 4337-4340 (1984).
Seebach et al., N,O-Acetals from Pivalaladehyde and Amino Acids for the a-Alkylation with Self Reproduction of the Center of Chirality. Enolates of 3-Benzoyl-2(tertbutyl)-1,3-oxazolidin-5-ones, Helvetica Chimica Acts, vol. 68, pp. 1243-1250 (1985).
Corey et al., Cleavage of Allyloxycarbonyl Protecting Group from Oxygen and Nitrogen under Mild Conditions by Nickel Carbonyl, J. Org. Chem., vol. 38, No. 18, pp. 3223-3224 (1973).
Wlodawer et al., Science, vol. 245, p. 616 (1989).
Renaud et al., J. Biol. Chem., vol. 258, p. 8312 (1983).
Veber et al., J. Org. Chem., vol. 42, p. 3286 (1977).
Atherton et al., J. Org. Chem., vol. 42, p. 3286 (1977).
Kunz et al., "The Allyloxycarbonyl (Aloe) Moiety-Conversion of an Unsuitable into a Valuable Amino Protecting Group for Peptide Synthesis", Angew. Chem. Int. Ed. Engl. 23: 436-437 (1984).
Bolis, G. et al., "Renin Inhibitors. Dipeptide analogues of angiotensinogen incorporating transition-state, nonpeptide replacements at the scissile bond" J. Med. Chem. 30: 1729-1737 (1987).
Haber, E. et al., "Renin Inhibitors. A Search for Principles of Design" J. of Cardiovascular Pharm. 10: S54-S58 (1987).
Greene et al., Protective Groups in Organic Synthesis, 2d Ed., John Wiley & Sons, New York (1991).
Gross et al., The Peptide, vol. 9, pp. 1-38, Academic Press, New York, N.Y. (1983).
Iizuka et al., J. Med Chem., vol. 31, p. 701 (1988).
Luly et al., J. Med. Chem. vol. 31, p. 2264 (1988).
Magrath et al., J. Med. Chem., vol. 35, p. 4279 (1992).
Kunz et al., Angew. Chem. Int. Ed. Engl., vol. 7. p. 7 (1968).

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