Pyrroline N-oxide derivatives

Details Pyrroline N-oxide derivatives Pyrroline N-oxide derivatives

1993-04-16

1994-10-11

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548518, 5483037, C07D20746, C07D40312, C07D49502

Patent

active

053548710

ABSTRACT:
Derivatives of 3,5-substituted pyrroline N-oxides having substituents in the 4-position have been prepared, with the 4-position substituents being selected from certain ester, polyether, and alkanoyl groups, the latter having components which bind to biological substrates. These specific derivatives are effective as spin traps for different types of free radicals to form persistent nitroxide adducts of extended half life. These adducts can be characterized by ESR spectrometry technique and provide information e.g. concerning the identification of free radicals.

REFERENCES:
A. Dehnel et al., J. Org. Chem., 53, pp. 1566-1567 (1988).
G. M. Rozen, J. Med. Chem., 31, pp. 428-432 (1988).

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