Pyrrolimidazolones useful as renin inhibitors

Details Pyrrolimidazolones useful as renin inhibitors Pyrrolimidazolones useful as renin inhibitors

1990-11-16

1991-12-24

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23500

Patent

active

050754513

ABSTRACT:
A compound of the formula: ##STR1## wherein A is ##STR2## in which X is .dbd.CH-- or .dbd.N--; R.sup.2 is hydrogen, alkyl, phenyl, benzyl or phenethyl; Y is --CH.sub.2 --, --NH-- or --O--; and Z is --H.sub.2 or .dbd.O; B is His, Leu, Ile, Nva, Nle, Ala or Val; and R.sup.1 is hydrogen, alkyl, phenyl or phenylalkyl; or a pharmaceutically acceptable salt thereof are renin inhibitors.

REFERENCES:
patent: 4312809 (1982-01-01), Haugwitz
patent: 4814342 (1989-03-01), Hoover et al.

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