Pyrrolidones with anti-HIV activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S422000, C514S423000, C546S276400, C548S518000, C548S530000

Reexamination Certificate

active

07601742

ABSTRACT:
The present invention relates to inhibition of viruses, e.g., HIV using pyrrolidones and compounds related to pyrrolidones. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to methods of prophylaxis, and therapy related to HIV infection and related disease states such as AIDS.

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Keller, Thomas H. et al, “Synthesis and Structure-Activity Relationship of N-Arylrolipram Derivatives as Inhibitors of PDE4 Isozymes,” Chem. Pharm. Bull. 2001 pp. 1009-1017, vol. 49(8).
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Keller, Thomas H., et al., “Synthesis and Structure-Activity Relationship of N-Arylrolipram Derivatives as Inhibitors of PDE4 Isozymes”,Chem. Pharm. Bull, 2001, pp. 1009-1017, vol. 49(8).
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Aebischer, et al., “Synthesis ofN-Arylrolipram Derivatives—Potent and Selective Phosphodiesterase-IV Inhibitors—By Copper Catalyzed Lactam-Aryl Halide Coupling”,Heterocyles, vol. 48, No. 11, pp. 2225-2229, 1998.

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