Pyrrolidinyl pyridones for treating pain

Details Pyrrolidinyl pyridones for treating pain Pyrrolidinyl pyridones for treating pain

1994-11-29

1996-09-24

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514428, 540597, 546188, 548567, 548568, A61K 31445, C07D40108

Patent

active

055591302

ABSTRACT:
A compound selected from the group consisting of all possible racemic, enantiomeric and diastereoisomeric forms of a compound of the formula ##STR1## wherein E and G together form a group selected from the group: ##STR2## consisting of a) ##STR3## or, if appropriate, its tautomer ##STR4## and ##STR5## or E is --COOR.sub.3 and G is ##STR6## wherein A, Y, R, Ra, R.sub.1 and R.sub.2 are as defined in the specification.

REFERENCES:
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Lentia et al. "3-Amino-triiodoaminobenzoyl compounds for us as x-ray contrast agents" CA 56:5585d (1962).
Casini et al "N-diakylaminomethy and N-cycloalkyeniminomethy-ethyl-phenyl glutarimides" CA 60:7985f (1964).
Fleck et al. "Comparison of the biological efficiency of C and N Mannich bases . . . " CA 82:25657a (1975).
Malec et al. "Pharmacological properties of new derivatives of glutethimide" CA 84:12451v (1976).
Hook et al. "Synthesis of polyamine-linked bis daunmycin hydrozones and their interaction with DNA" CA 112:91218x (1990).
McOmie : "Protective groups in organic chemistry" Plenum Press, P. 43, 49, 52, 61 (1973).

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