Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-12-18
2011-12-27
Havlin, Robert (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
08084623
ABSTRACT:
Compounds of the formula:or pharmaceutically acceptable salts thereof,wherein m, n, Ar, R1, R2, Raand Rbare defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
REFERENCES:
patent: 2248018 (1941-07-01), Otto
patent: 4341698 (1982-07-01), Carr et al.
patent: 4443451 (1984-04-01), Kennis et al.
patent: 7115750 (2006-10-01), Kato et al.
patent: 2002/0151712 (2002-10-01), Lin et al.
patent: 2004/0034019 (2004-02-01), Tomlinson et al.
patent: 2005/0090504 (2005-04-01), Gong et al.
patent: 2006/0167044 (2006-07-01), Arnaiz et al.
patent: 30 39 974 (1981-05-01), None
patent: 0 161 874 (1989-09-01), None
patent: 2 468 592 (1981-05-01), None
patent: 931789 (1961-03-01), None
patent: 2 061 0937 (1981-05-01), None
patent: WO 91/09594 (1991-07-01), None
patent: WO 96/26196 (1996-08-01), None
patent: WO 96/26196 (1996-08-01), None
patent: WO 96/41802 (1996-12-01), None
patent: WO 97/19073 (1997-05-01), None
patent: WO 98/31669 (1998-07-01), None
patent: WO 01/14331 (2001-03-01), None
patent: WO 01/14331 (2001-03-01), None
patent: WO 02/22572 (2002-03-01), None
patent: WO 02/22572 (2002-03-01), None
patent: 02072548 (2002-09-01), None
patent: WO 03/017927 (2003-03-01), None
patent: WO 03/017927 (2003-03-01), None
patent: 03068221 (2003-08-01), None
patent: WO 03/088908 (2003-10-01), None
patent: WO 03/088908 (2003-10-01), None
patent: 2004022712 (2004-03-01), None
patent: WO 2004/024720 (2004-03-01), None
patent: WO 2004/033427 (2004-04-01), None
patent: WO 2004/080925 (2004-09-01), None
patent: WO 2004/080925 (2004-09-01), None
patent: WO 2005/047250 (2005-05-01), None
patent: WO 2005/047253 (2005-05-01), None
patent: WO 2005/082904 (2005-09-01), None
patent: 2005123716 (2005-12-01), None
patent: WO 2006/003147 (2006-01-01), None
patent: WO 2006/016912 (2006-02-01), None
patent: WO 2006/016912 (2006-02-01), None
patent: WO 2006/034341 (2006-03-01), None
patent: WO 2006/034341 (2006-03-01), None
patent: WO 2006/066989 (2006-06-01), None
patent: 2006081332 (2006-08-01), None
patent: WO 2006/086609 (2006-08-01), None
patent: WO 2006/086609 (2006-08-01), None
patent: 2007068619 (2007-06-01), None
patent: 2007117401 (2007-10-01), None
Kubinyi (3D QSAR in Drug Design: Ligand-Protein Interactions and Molecular Similarity, vol. 2-3, Springer, 1998, 800 pages), TOC and pp. 243-244 provided.
Rhoden et al. (J. Bioorg. Med. Chem. 13 (2005) 5623-34).
Bergel et al. (CAPLUS abstract of GB 584877).
Beer, B., et. al. “DOV 216,303, a “Triple” Reuptake Inhibitor: Safety, Tolerability, and Pharmacokinetic Profile,”J. Clinical Pharmacology(2004) vol. 44, pp. 1360-1367.
Isaacson, J., et. al. “Expeditious Access to Unprotected Racemic Pyroglutamic Acids,”J. Org. Chem. (2007) vol. 72, pp. 3913-3916.
Ong, H.H., et. al. “Novel Tetracyclic Spiropiperidines. II. Synthesis of 2-Aryl-2,3-dihydrospiro[benzofuran-3,4′-piperidines] (1,2),”J. Heterocyclic Chem. (1981) vol. 18, pp. 815-820.
Rhoden, J.B., et. al. “Structure-activity studies of 3′-4′ dichloro-meperidine analogues at dopamine and serotonin transporters,”Bioorganic&Medicinal Chem. (2005) vol. 13, pp. 5623-5634.
Skolnick, P., et. al. “Antidepressant-like Actions of DOV 21,947: a “triple” Reuptake Inhibitors,”European J. Pharmacology(2003) vol. 461, pp. 99-104.
Wagner, P.J., et. al. “Absence of Intramolecular Charge-Transfer Quenching in Photoexcited 4-Benzoylpiperidines,”J. Am. Chem. Soc. (1977) vol. 99, pp. 1858-1863.
Burkholder, T.P., et. al. “Synthesis and Structure-Activity Relationships for a Series of Substituted Pyrrolidine NK1/NK2Receptor Antagonists,”Bioorganic&Medicinal Chemistry Letters(1997) vol. 7 (19), pp. 2531-2536.
Gakis, N., et. al. “Zur Photodimerisierung von 3-Phenyl-2H-azirinen),”Helvetica Chimica Acta(1972) vol. 55, pp. 748-752.
Ikeda, M. et. al. “A Formal Total Synthesis of (−−)-Cephalotaxine,”Chem. Pharm. Bull. (1999) vol. 47 (7), pp. 983-987.
Nakanishi, M., et. al., “Studies of Piperidine Derivatives. 1,”Journal of Medicinal Chemistry(1970) vol. 13 (4), pp. 644-648.
Nishi, T., et. al., “Combined NK,1and NK2Tachykinin Receptor Antagonists: Synthesis and Structure-Activity Relationships of Novel Oxazolidine Analogues,”Bioorg. &Medicinal Chem. Lett. (1999) vol. 9, pp. 875-880.
Scopes, D. I. C., et. al. “New κ-Receptor Agonists Based upon a 2-[(Alkylamino)methyl]piperidine Nucleus,”J. Med. Chem. (1992) vol. 35, pp. 490-501.
Seebach, D., et. al. “Alkylation of Amino Acids without Loss of the Optical Activity: Preparation of α-Substituted Proline Detrivatives. A Case of Self-Reproduction of Chirality,”J. Am. Chem. Soc. (1983) vol. 105, pp. 5390-5398.
Wantanabe, Y., et. al. “Synthesis and 5-HT2Antagonist Activity of Bicyclic 1,2,4-Triazol-3(2H)-one and 1,3,5-Triazine-2,4(3H)-dione Derivatives,”J. Med. Chem. (1992) vol. 35, pp. 189-194.
Janicki, P., et. al. “Analgesic Activity and Opiate Receptor Affinity of New Derivatives of 'N-Butylpiperidine,”Pol. J. Pharmacol. Pahrm. 1980, vol. 32, pp. 141-148.
Rylski, L., et. al. “Synteza Niektorych 1-[3-(Dwualkiloamino)-Propylo]-4-Acylo-4-Fenylopiperydyn,”Acta Polon. Pharm. 1970, No. 3, pp. 213-221.
Iyer Pravin
Lin Clara Jeou Jen
Lucas Matthew C.
Lynch Stephen M.
Madera Ann Marie
Hall Robert C.
Havlin Robert
Roche Palo Alto LLC
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