Pyrrolidine derivatives for the treatment of cholecystokinine an

Details Pyrrolidine derivatives for the treatment of cholecystokinine an Pyrrolidine derivatives for the treatment of cholecystokinine an

1996-12-18

1998-02-10

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

548533, C07D20712, A61K 3140

Patent

active

057169365

DESCRIPTION:

BRIEF SUMMARY
This application is a 371 of PCT/FR9500796 filed Jun. 16, 1995.
The present invention relates to derivatives of formula: ##STR1## to their salts, to their preparation and to the medicaments containing them.
In formula (I), straight or branched chain and optionally mono- or polyunsaturated, a cycloalkyl radical containing 3 to 12 carbon atoms and optionally mono- or polyunsaturated, a polycycloalkyl radical containing 6 to 12 carbon atoms and optionally mono- or polyunsaturated, a phenylalkyl radical in which the phenyl ring is optionally substituted (with one or more substituents chosen from alkyl and alkoxy radicals or halogen atoms), a diphenylalkyl or cinnamyl radical, a pyridyl radical optionally substituted with one or more alkyl radicals, a furyl radical optionally substituted with one or more alkyl radicals, a thienyl radical optionally substituted with one or more alkyl radicals, a quinolyl radical optionally substituted with one or more alkyl radicals, a naphthyl radical optionally substituted with one or more alkyl radicals, an indolyl radical optionally substituted with one or more alkyl radicals or a phenyl radical optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy, hydroxyl, nitro, amino, monoalkylamino, dialkylamino, alkoxycarbonyl, --CO--NR.sub.8 R.sub.9, --NH--CO--CH.sub.3, trifluoromethyl and trifluoromethoxy radicals, --(CH.sub.2).sub.m --O--CO--R.sub.11 or --(CH.sub.2).sub.m --NR.sub.12 R.sub.13 or an oxazolinyl radical optionally substituted with one or more alkyl radicals or a 3-alkyloxadiazolyl radical, more substituents chosen from halogen atoms and alkyl, alkoxy and alkylthio radicals), a naphthyl, indolyl or quinolyl radical, or a phenylamino radical in which the phenyl ring is optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy, alkylthio, trifluoromethyl, carboxyl, alkoxycarbonyl, hydroxyl, nitro, amino, acyl, cyano, sulphamoyl, carbamoyl, hydroxyiminoalkyl, alkoxyiminoalkyl, hydroxyaminocarbonyl, alkoxyaminocarbonyl, 5-tetrazolyl, 5-tetrazolylalkyl, trifluoromethylsulphonamido, alkylsulphinyl, mono- or polyhydroxyalkyl, sulpho, -alk-O--CO-alk, -alk-COOX, -alk-O-alk, -alk'-COOX, --O-alk-COOX, --CH.dbd.CH--COOX, --CO--COOX, -alk-SO.sub.3 H (in salt form), --CH.dbd.CH-alk', --C(.dbd.NOH)--COOX, --S-alk-COOX, --SO-alk-COOX, --SO.sub.2 -alk-COOX, --O--CH.sub.2 -alk'-COOX, --CX.dbd.N--O-alk-COOX, -alk-N(OH)--CO-alk, -alk-SO.sub.2 H, --SO.sub.2 --NH--CO--R.sub.14, --SO.sub.2 --NH--SO.sub.2 --R.sub.14, --CO--NH--CO--R.sub.14, --CO--NH--SO.sub.2 --R.sub.14, --B(OH).sub.2, --C(NH.sub.2).dbd.NOH, --SO.sub.2 --NH--R.sub.15, --CO--NH--R.sub.15, ##STR2## and 2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl radicals, R.sub.6 represents a hydrogen atom or an alkyl or phenylalkyl radical, --NR.sub.8 R.sub.9 or a phenylsulphonyl radical in which the phenyl ring is substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy, hydroxyl, nitro, amino, monoalkylamino, dialkylamino, acylamino, trifluoromethyl and trifluoromethoxy radicals, phenyl radical which is optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy and alkylthio radicals, which is optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy and alkylthio radicals, to which they are attached, a saturated or unsaturated mono- or polycyclic heterocycle containing 4 to 9 carbon atoms and one or more hetero atoms (O, N) and is optionally substituted with one or more alkyl radicals, phenyl or --NR.sub.12 R.sub.13 radical, --NR.sub.12 R.sub.13 radical, cycloalkyl or phenylalkyl radical or a phenyl radical which is optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy and alkylthio radicals, radical or a phenyl radical which is optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy and alkylthio radicals, atom to which they are attached, a saturated or unsaturated mono- or pol

REFERENCES:
patent: 4593102 (1986-06-01), Shanklin, Jr.
patent: 4642348 (1987-02-01), Shanklin, Jr.
patent: 5610144 (1997-03-01), Capet

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