Pyrrolidine derivatives as oxytocin antagonists

Details Pyrrolidine derivatives as oxytocin antagonists Pyrrolidine derivatives as oxytocin antagonists

2006-10-03

2006-10-03

McKane, Joseph K. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S326000, C514S333000, C514S426000, C514S424000, C548S406000, C548S557000, C548S566000, C548S571000, C548S544000, C546S208000

Reexamination Certificate

active

07115754

ABSTRACT:
The present invention relates to novel pyrrolidine derivative of formula (I), its geometrical isomers, its optically active forms as enantiomers, diastereomers, mixtures of these and its racemate forms, as well as salts thereof, wherein R1is selected from the group comprising or consisting of H and C1–C6-alkyl, for the prevention and/or treatment of preterm labor, premature birth or dysmenorrhea

REFERENCES:
patent: 99 52868 (1999-10-01), None
patent: 01 72705 (2001-10-01), None
Maggi, Marlo et al. “Human Myometrium during Pregnancy Contains and Responds to V1 Vasopressin Receptors as well as Oxytocin Receptors”, Journal of Clinical Endocrinology and Metabolism, vol. 70, No. 4, pp. 1142-1154 1990.
Mitchell, B. F. et al. “Oxytocin and its Receptor in the Process of Parturition”, J. Soc. Gynecol. Investig. vol. 8, No. 3, pp. 122-133 2001.
Thornton, Steven et al. “Oxytocin antagonists: clinical and scientific considerations”, Experimental Physiology, vol. 86, No. 2, pp. 297-302 2001.
Evans, Ben E. et al. “Orally Active, Nonpeptide Oxytocin Antagonists”, J. Med. Chem. vol. 35, pp. 3919-3927 1992.
Cook, Neil et al. “SPA: a revolutionary new technique for drug screening”, Pharmaceutical Manufacturing International, pp. 49-53 1992.
Gimpl, Gerald et al. The Oxytocin Receptor System: Structure, Function, and Regulation, vol. 81, No. 2, pp. 629-683 2001.

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