Pyrrolidine compounds

Details Pyrrolidine compounds Pyrrolidine compounds

2010-02-19

2011-12-06

Wilson, James O (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C544S350000, C544S372000, C546S114000, C546S208000, C546S276400, C548S146000, C548S470000

Reexamination Certificate

active

08071787

ABSTRACT:
A compound of the following formula:wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, X, Y, and Z are as defined herein. Also disclosed is a method for inhibiting actively of fibroblast activation protein or for treating cancer or inflammation conditions with such a compound.

REFERENCES:
Kanemasa, et al. Chem. Lett., 9, 1992, 1801-1804.
Tran, Thuy, et al. “Synthesis and structure-activity relationship of N-acyl-Gly-, N-acyl-Sar- and N-blocked-boroPro inhibitors of FAP, DPP4, and POP”Bioorganic & Medicinal Chemistry Letters 17(2007) pp. 1438-1442.
Hu, Yi, et al. “Synthesis and structure-activity relationship of N-alkyl Gly-boro-Pro inhibitors of DPP4, FAP, and DPP7”Bioorganic & Medicinal Chemistry Letters 15(2005) pp. 4239-4242.

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