Pyrrolidine compound and a process for preparing the same

Details Pyrrolidine compound and a process for preparing the same Pyrrolidine compound and a process for preparing the same

2005-05-27

2011-10-11

Andres, Janet (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S349000, C548S544000

Reexamination Certificate

active

08034949

ABSTRACT:
The present invention relates to a novel pyrrolidine compound, which has a potent antagonistic activity against central cannabinoid (CB1) receptor, having the formula [I]: wherein each of R1and R2is (A) optionally substituted aryl (or heteroaryl) group, or (B) both of the groups combine to form a group of the formula: one of R3and R4is hydrogen and another is hydrogen, hydroxyl, hydroxyalkyl, etc., or both of R3and R4combine to form oxo group, R5is hydrogen or alkyl, Y is single bond, oxygen atom or a group of the formula: —N(R7)—, R6is optionally substituted hydrocarbon group or optionally substituted cyclic group, R7is alkyl or alkyloxycarbonylalkyl, provided that R6is not 4-amino-5-chloro-2-methoxyphenyl group when Y is single bond and one of the R3and R4is hydrogen and another is hydroxymethyl, or a pharmaceutically acceptable salt thereof.

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