Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-08-27
2000-12-26
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514212, 514213, 514255, 514278, 514307, 514316, 540595, 540602, 544372, 546 18, 546148, 546186, 546187, 546191, 546208, A61K 31445, C07D40106
Patent
active
06166037&
ABSTRACT:
The present invention is directed to pyrrolidine and piperidine compounds of the formula I: ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4a, R.sup.4b, R.sup.4c, R.sup.4d, R.sup.4e, R.sup.4f, R.sup.4g, R.sup.4h, m, n, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.
REFERENCES:
patent: 5635510 (1997-06-01), Burkholder et al.
patent: 5686424 (1997-11-01), Connell et al.
Setoi et al. "1-Arylsulfonyl2-carboxypiperidino or carboxyphenyl amino . . . " CA 113:40445, 1990.
Weiss et al. "Effects of amino acid amides and aminothiols on . . . " CA 114:94966, 1990.
Caldwell, et al., USSN 09/241,486 (filed Feb. 1, 1999).
Berk Scott C.
Budhu Richard J.
Hale Jeffrey J.
Holson Edward
Lynch Christopher
Chang Ceila
Merck & Co. , Inc.
Rose David L.
Thies J. Eric
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