Pyrrolidine and piperidine derivatives and treatment of neurodeg

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514408, 514422, 514423, 514428, A61K 3140, A61K 31445, A61P 2500

Patent

active

061536245

ABSTRACT:
The present invention relates to the use of pyrrolidine and piperidine derivatives of the general formula ##STR1## wherein R.sup.1 and R.sup.2 are, independently from each other, hydrogen, lower alkoxy, hydroxy, halogen, --CONH.sub.2 or --C(O)O-lower alkyl; or taken together are --O--CH.sub.2 O;

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Fischer et al., J. of Pharmacology & Expermental Therapeutics, 283, 1285-1292. (1997).
Kaiser et al., J. Org. Chem., 49, 4203-4209 (1984).
Aizenman E et al. Brain Res. 551(1-2), 355-7, 1991.

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