Pyrrolidine and piperidine derivatives and treatment of neurodeg

Details Pyrrolidine and piperidine derivatives and treatment of neurodeg Pyrrolidine and piperidine derivatives and treatment of neurodeg

1999-01-20

2000-01-18

Huang, Evelyn Mei

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142305, 514302, 544105, 546115, 546116, 548217, A61K 3142, A61K 31445, A61K 31535, C07D26352, C07D47104

Patent

active

060158247

ABSTRACT:
The present invention relates to the use of pyrrolidine and piperidine derivatives of the general formula ##STR1## wherein R.sup.1 and R.sup.2 are, independently from each other, hydrogen, lower alkoxy, hydroxy, halogen, --CONH.sub.2 or --C(O)O-lower alkyl; or taken together are --O--CH.sub.2 O;

REFERENCES:
patent: 3941796 (1976-03-01), Sankey et al.
patent: 4407670 (1983-10-01), Crabb
patent: 4548951 (1985-10-01), Muchowski et al.
patent: 4558066 (1985-12-01), Waterbury
G. Fischer, V. Mutel, G. Trube, P. Malherbe, J.N.C. Kew, E. Mohacsi, M.P. Heitz and J. A. Kemp, J. of Pharmacology & Expermental Therapeutics, 283, (1997), 1285-1292.
H.-P. Kaiser and J. M. Muchowski, J. Org. Chem., 49, (1984), 4203-4209.

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