Pyrrolidine and azetidine compounds as CCR5 antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S392000, C514S422000, C546S016000, C548S518000, C548S301400

Reexamination Certificate

active

10538134

ABSTRACT:
The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).

REFERENCES:
patent: 5861416 (1999-01-01), Burkholder et al.
patent: 5861417 (1999-01-01), Burkholder et al.
patent: WO9426735 (1994-11-01), None
STN search result of WO 94/26735, Burkholder et al., Nov. 1994, PCT.
Wikipedia for hetercyclic compound, on-line edition.
TYLE, Iontophoretic Devices for Drug Delivery, Pharmaceutical Research 3(6):318-326 (1986).

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