Pyrrolidine-3,4-dicarboxamide derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S422000, C514S423000, C546S278100, C548S517000, C548S530000

Reexamination Certificate

active

07550487

ABSTRACT:
The invention is concerned with novel pyrrolidine-3,4-dicarboxamide derivatives of formula (I)wherein R1to R9and X are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.

REFERENCES:
patent: 6429213 (2002-08-01), Xue et al.
patent: 6858626 (2005-02-01), Xue et al.
patent: 7030141 (2006-04-01), Bigge et al.
patent: 2003/0139597 (2003-07-01), Xue et al.
patent: 2006/0106016 (2006-05-01), Boehringer et al.
patent: 2006/0142362 (2006-06-01), Boehringer et al.
patent: 2006/0247238 (2006-11-01), Zbinden et al.
patent: 2007/0015812 (2007-01-01), Boehringer et al.
patent: 2007/0049587 (2007-03-01), Zbinden et al.
patent: 2007/0112001 (2007-05-01), Anselm et al.
patent: 2007/0112012 (2007-05-01), Boehringer et al.
patent: 2007/0249683 (2007-10-01), Zbinden et al.
patent: WO 02/22575 (2002-03-01), None
patent: WO 03/045912 (2003-06-01), None
Al-Obeidi, F., et al., Expert opinion on Therapeutic Patents, Ashley Publications, GB, vol. 9, pp. 931-953 (1999), XP001000512.
Cheng, Y. C. and Prusoff, W. H.,Relationship Between The Inhibition Constant(Ki)And The Concentration Of Inhibitor Which Causes 50 Per Cent Inhibition(I50)Of An Enzymatic Reaction, Biochem. Pharmacol., vol. 22, pp. 3099-3108 (1973).
Lottenberg et al.,The Action Of Thrombin On Peptide p-Nitroanilide Substrates: Substrate Selectivity And Examination Of Hydrolysis Under Different Reaction Conditions, Biochim Biophys Acta., vol. 742, pp. 539-557 (1983).
Eadie, G. S.,The Inhibition of Cholinesterase By Physostigmine and Prostigmine, J. Biol. Chem., vol. 146, pp. 85-93 (1942).
Sarmiento et al.,Chemoenzymatic Preparation Of Non-Racemic N-Boc-Pyrrolidine-3,4-Dicarboxylic Acid 3-Ethyl Esters And Their 4- Hydroxymethyl Deriviatives, Tetrahedron Asymmetry, vol. 14, pp. 1547-1551 (2003).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Pyrrolidine-3,4-dicarboxamide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrrolidine-3,4-dicarboxamide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrrolidine-3,4-dicarboxamide derivatives will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4108365

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.