Pyrrolidin-3,4-diol derivatives of heptitols and preparation the

Details Pyrrolidin-3,4-diol derivatives of heptitols and preparation the Pyrrolidin-3,4-diol derivatives of heptitols and preparation the

1992-09-29

1993-10-05

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548110, 534590, C07D20712, C07D40706

Patent

active

052507033

ABSTRACT:
Novel heptitol analogues of mannofuranose and their syntheses from .delta.-lactones of heptonic acids are disclosed. The novel heptitols are (A) 2,5-dideoxy-2,5-imino-D-glycero-D-talo-heptitol and (b) 1-amino-2,5-anhydro-1-deoxy-D-glycero-D-talo-heptitol. These novel heptitol compounds are useful inhibitors of glycosidases.

REFERENCES:
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patent: 5136036 (1992-03-01), Fleet et al.
Choi et al., Tetrahedron Lett. 32, 5517-5520 (1991).
Bruce et al., Tetrahedron 46(1), 19-32 (1990).
Beacham et al., Tetrahedron:Asymmetry 2 (9), 883-900 (1991).
Cenci di Bello et al., Biochem. J. 259, 855-861 (1989).
Carpenter et al., Tetrahedron Lett. 30, 7261 (1989).

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