Pyrrolidin-2-one derivatives as inhibitors of factor xa

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S324000, C544S141000, C546S202000

Reexamination Certificate

active

11384094

ABSTRACT:
The invention relates to compounds of formula (Ic)processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.

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Mack et al., “Design, synthesis and biological activity of novel rigid amidino-phenylalanine derivatives as inhibitors of thrombin,” J. Enzyme Inhibition, vol. 9, Issue 1, pp. 73-86 (1995).
J. Enzyme Inhibition, 1995, 9(1), pp. 73-86.

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