Pyrroles substituted by oligonucleotides

Details Pyrroles substituted by oligonucleotides Pyrroles substituted by oligonucleotides

2003-12-16

2008-11-04

Riley, Jezia (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S025300, C435S006120

Reexamination Certificate

active

07446186

ABSTRACT:
The invention relates to novel pyrrole derivatives of the formula (I) which make it possible to immobilize and address oligonucleotides by electropolymerization. Said invention also relates to thus produced electroactive polymers and to methods for using them for detecting, identifying and dosing analytes in a sample. (I) wherein R1is one type of oligonucleotide, Y is S or O, X is a spacer arm selected from —(CH2)—O—, —(CH2)<SB>P</SB>O—[(CH2)2—O]q—, —(CH2)r; —CO—NR′—(CH2)r—O—, —CH2r—NCH3—(CH2)r—O—, —CH2)rCO—NR′—[CH2)2—O]s—, —(CH2)rNCH3[(CH2)2—O]<SB>S</SB>—, R′ is H or CH3, n is an integer number ranging from 1 to 5, p is an integer number ranging from 1 to 2, q is an integer number ranging from 1 to 4, r is an integer number ranging from 1 to 3, r′ is an integer number ranging from 1 to 3, s is an integer number ranging from 1 to 3, n, p, q, r, r′ and s are identical or different, a pyrrole cycle is substituted in a position 2, 3, 4 or 5.

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