Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-12-19
1992-10-06
Chan, Nicky
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548530, A61K 3140, C07D207333
Patent
active
051532174
ABSTRACT:
A novel pyrrolealdehyde derivative represented by the following formula (I): ##STR1## wherein R represents C.sub.10 -C.sub.16 alkyl unsubstituted or substituted by at least one substituent selected from the group consisting of halo, hydroxy, amino, carbamoyl, C.sub.1 -C.sub.5 alkylamino, C.sub.2 -C.sub.6 dialkylamino, C.sub.2 -C.sub.6 acylamino, C.sub.1 -C.sub.5 alkylthio, mercapto, C.sub.2 -C.sub.6 acyloxy, carbamoyloxy, C.sub.6 -C.sub.12 aryl and C.sub.3 -C.sub.7 cycloalkyl; or C.sub.10 -C.sub.16 alkenyl having at least one vinyl, and a pharmaceutically acceptable salt thereof are provided. The compounds are highly effective in reducing the level of triglyceride and cholesterol in serum, and useful as an active ingredient of a pharmaceutical composition for treating hyperlipemia and arteriosclerosis.
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Hirata Mayumi
Shirasaka Tadashi
Taniguchi Masao
Umezu Kohei
Chan Nicky
Mitsubishi Kasei Corporation
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