Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-05-30
1992-07-07
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514424, 514314, 546172, 548517, 548527, 548542, A61K 3140, C07D21536, C07D20748, C07D40902
Patent
active
051283662
ABSTRACT:
The compounds of the present invention inhibit HMG-CoA reductase, and subsequently suppress the synthesis of cholesterol. And they are useful in the treatment of hypercholesterolemia, hyperlipoproteinemia, and atherosclerosis. The compounds have the formula ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 each is independently hydrogen, optionally substituted lower alkyl, or optionally substituted aryl; R.sup.4 is lower alkyl, aralkyl, aryl, or heteroaryl, each of which is optionally substituted; X is vinylene or ethylene; Y is ##STR2## where R.sup.5 is hydrogen, lower alkyl, aryl, aralkyl, or a cation capable of forming a non-toxic pharmaceutically acceptable salt.
REFERENCES:
patent: 4885307 (1989-12-01), Toja et al.
Hirai Kentaro
Ishiba Teruyuki
Koike Haruo
Watanabe Masamichi
Lee Mary C.
McKane Joseph K.
Shinogi & Co., Ltd.
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