Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2004-08-27
2009-12-01
Saeed, Kamal A (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S372000, C514S378000, C514S381000, C514S383000, C514S406000, C548S253000, C548S364100, C548S517000, C548S530000
Reexamination Certificate
active
07625932
ABSTRACT:
The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression. The compounds act as potentiators on glutamate receptors, in particular AMPA and the GluR family.
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Ornstein, Paul L. et al., Biarylpropylsulfonamides as Novel, Potent Potntiators of 2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)-propanoic Acid (AMPA) Receptors, J. Med Chem, 2000, 4354-4358, 43.
Albaugh Pamela Ann
Castano Mansanet Ana Maria
Dominguez-Manzanares Esteban
Hong Jian Eric
Hornback William Joseph
Combs Tonya L.
Eli Lilly and Company
Saeed Kamal A
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