Pyrrole-2,5-dione derivatives as Liver X receptor modulators

Details Pyrrole-2,5-dione derivatives as Liver X receptor modulators Pyrrole-2,5-dione derivatives as Liver X receptor modulators

2004-07-08

2008-10-07

Morris, Patricia L (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S278700

Reexamination Certificate

active

07432288

ABSTRACT:
The present invention relates to certain novel compounds of the Formula Ito processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR)α(NR1H3) and/or β(NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them.

REFERENCES:
patent: WO 00/06564 (2000-02-01), None
patent: WO-00/21927 (2000-04-01), None
patent: WO-01/03705 (2001-01-01), None
patent: WO 01/13916 (2001-03-01), None
patent: WO 01/74771 (2001-10-01), None
Vippagunta et all., “Crystalline solids”, Advanced Drug Delivery Reviews, 48 (2001), 3-26.
Guillory “Generation of polymorphs, etc.,” in Brittain ed., Polymorphism in Pharmaceutical Solids, 95, Marcel Dekker, NY, 1999, 183-226.
Laffitte et al. “Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue” PNAS 100: 5419-5424 (2003).

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