Pyrone derivatives as protease inhibitors and antiviral agents

Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

544149, 544360, 5462801, 5462821, 548202, 548238, 549 28, 549273, 549274, C07D30900, C07D31900, C07D40900, C07D40500

Patent

active

060051035

ABSTRACT:
The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.

REFERENCES:
patent: 3206476 (1965-09-01), Collins
patent: 3818046 (1974-06-01), Harris et al.
patent: 3931235 (1976-01-01), Harris et al.
S. Thaisrivangs, et al., J. Med. Chem., 1994, 37, 3200-3204.
M. Ruwart, et al., American Association of Pharmaceutical Scientists Meeting--Abstract/PDD 7290, Nov. 6-10, 1994, San Diego.
C. Goetschel and C. Mentzer, Bull Soc Chim Fr, 1962, No. 75, p. 365.
N. Kohl, et al., Proc. Nat. Acad. Sci. USA,85:1988,4689-90.
J.C. Craig, et al, Antiviral Research, 16:1991, 295-305.
A.G. Tomasselli, et al., Chimica Oggi, 9:1991,6-27.
T. Meek, J. Enzyme Inhibition, 6: 1992, 65-98.
R. Nagorny, et al, AIDS, 7:1993, 129-130.
D.P. Fairlie, et al., Biochem. Biophys. Res. Comm., 188: 1992, 631-637.
D. Richman, "Control of Virus Diseases," 45th Symposium of the Society for General Microbiology, 1990, 261-313.
H. Toh, et al., Nature, 1985, 315:691.
J. Kay, et al., Biochim. Biophys. Acta 1: 1990, 1048.
C. Cameron, et al., J. Biological Chem. 168, 1993, 11711-7.
M. Graves, Structure and Function of the Aspartic Protease 1991, 395-405.
C. Peng, et al., J. Virol.,63: 1989, 2550-2556.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Pyrone derivatives as protease inhibitors and antiviral agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrone derivatives as protease inhibitors and antiviral agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrone derivatives as protease inhibitors and antiviral agents will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-506513

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.