Pyroglutamic acid esters, their synthesis and use in topical pro

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514422, 548518, 548519, 548534, A61K 3140, C07D20712, C07D40312, C07D40314

Patent

active

047742550

ABSTRACT:
Esters of pyroglutamic acid having the structure: ##STR1## where R' and R" are the same or different and are each represented by H or the grouping

REFERENCES:
patent: Re29003 (1976-10-01), Furlenmeier et al.
patent: 3839322 (1974-10-01), Furlenmeier et al.
patent: 3956323 (1976-05-01), Furlenmeier et al.
patent: 3957758 (1976-05-01), Furlenmeier et al.
J. G. Barrett and I. R. Scott, (1983) "Pyrrolidone Carboxylic Acid Synthesis in Guinea Epidermis", J. Invest. Dermatol. 81 122-124.
I. R. Scott-C. R. Harding and J. G. Barrett (1982) "Histidine-rich Protein of the Keratohyaline Granules", Bio. Chem.
Chemical Abstract 98:77945 (JF-A-57 91933-Pola Chemical Industries Inc.).
"Chemistry of Organic Compounds", Carl R. Noller, 3rd Edition, 1965.

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