Pyrimidones having histamine H.sub.2 -antagonist activity

Details Pyrimidones having histamine H.sub.2 -antagonist activity Pyrimidones having histamine H.sub.2 -antagonist activity

1981-03-27

1983-06-14

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

4242485, 42424856, 424251, 544 82, 544123, 544331, A61K 31505, C07D23924

Patent

active

043883176

ABSTRACT:
The compounds of this invention are 5-[dialkylaminoalkylfuranyl (or thienyl, phenyl or pyridyl)]-4-pyrimidones having histamine H.sub.2 -antagonist activity. A specific compound of this invention is 2-[2-(5-dimethylaminomethyl-2-furanylmethylthio)ethylamino]-5-(5-dimethyla minomethyl-2-furanylmethyl)-4-pyrimidone.

REFERENCES:
patent: 4154834 (1979-05-01), Brown et al.
patent: 4218452 (1980-08-01), Brown et al.
patent: 4234588 (1980-11-01), Brown et al.
patent: 4255440 (1981-03-01), Once et al.
Derwent Abstract 38240C (WP 8000966).
Derwent Abstract 64650C (EP 15138).

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