Pyrimidones and imidazolinones for treatment of shock

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514392, A61K 31505, A61K 31415

Patent

active

054829445

ABSTRACT:
The compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein X, m, n, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined herein are useful in the treatment of shock and other TNF.alpha.-related disorders.

REFERENCES:
patent: 4582834 (1986-04-01), Stenzel
patent: 4971959 (1990-11-01), Hawkins
Semmler et al., Immunology, 78, 520-525 (1993).

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