Pyrimidone derivatives as bronchodilators

Details Pyrimidone derivatives as bronchodilators Pyrimidone derivatives as bronchodilators

1989-06-23

1991-12-24

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544254, 544262, 544278, A61K 31495, C01D49504

Patent

active

050753100

ABSTRACT:
This invention relates to fused pyrimidine derivatives which have bronchodilator activity. A compound of this invention is 2-(2-propoxyphenyl)thieno[2,3-d]pyrimidin-4(3H)-one.

REFERENCES:
patent: 4039544 (1977-08-01), Broughton
patent: 4885301 (1989-12-01), Coates
Chemical Abstracts, vol. 83, No. 15, #131544s.
Broughton et al., "Anti-Allergic Activity of 2-Phenyl-8-azapurin-6-ones", J. Med. Chem., 18, 1117 (1975).
Hamilton et al., "Synthesis and Structure-Activity Relationships of Pyrazolo(4,3-d)pyrimidin-7-ones as Adenosine Receptor Antagonists", J. Med. Chem. 30, 91 (1987).
Baker et al., "Irreversible Enzyme Inhibitors CXXV. Active-Site-Directed Irreversible Inhibitors of Xanthine Oxidase Derived from Arylpurines and Pyrazole . . . Fluoride", J. Med. Chem. 11, 656 (1968).

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