Pyrimidocycloalkanes as a II antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514260, 544253, 544283, 544284, 544286, 544291, 544292, 544293, 544295, C07D23972, C07D23986, C07D23994

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active

052349365

ABSTRACT:
There are disclosed compounds of the general formula I: ##STR1## wherein X is H, NR.sup.12 R.sup.13, OR.sup.14, CN, F, Cl, I, Br, perfluoroalkyl, alkyl, alkoxy, alkyl-OH, alkoxyalkyl, --(CH.sub.2).sub.n CO.sub.2 R.sup.14, --(CH.sub.2).sub.n CONR.sup.12 R.sup.13 ;

REFERENCES:
patent: 4450162 (1984-05-01), Kamioka et al.
patent: 4464375 (1984-08-01), Kobayashi et al.
patent: 4749704 (1988-06-01), Iwata et al.
patent: 4880804 (1989-11-01), Carini et al.
Chiu et al., European Journal of Pharmacology, 157(1988) 13-21.

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