Pyrimido compounds having antiproliferative activity

Details Pyrimido compounds having antiproliferative activity Pyrimido compounds having antiproliferative activity

2006-10-03

2006-10-03

McKenzie, Thomas C. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C544S317000, C514S262100

Reexamination Certificate

active

07115740

ABSTRACT:
Disclosed are novel pyrimido compounds that are selective inhibitors of both KDR and FGFR kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds and methods of treating cancer.

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