Pyrimido[4,5-d][2]benzazepines useful as sedatives and anxiolyti

Details Pyrimido[4,5-d][2]benzazepines useful as sedatives and anxiolyti Pyrimido[4,5-d][2]benzazepines useful as sedatives and anxiolyti

1983-10-17

1985-10-22

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D48704

Patent

active

045487502

ABSTRACT:
There is presented a compound of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, lower alkyl, chloro, bromo, alkoxy, hydroxy, lower alkyl substituted thio and NR.sub.4 R.sub.5 wherein R.sub.4 and R.sub.5 are hydrogen, lower alkyl and di-substituted lower alkylamino lower alkyl; R.sub.2 is selected from the group consisting of hydrogen, lower alkyl and amino; R.sub.3 is selected from the group consisting of hydrogen, acyloxy and hydroxy; X is halogen and Y is hydrogen or halogen and the N-oxides thereof when R.sub.3 is hydrogen
and the pharmaceutically acceptable salts thereof.
The pyrimido[4,5-d][2]benzazepines are useful as anxiolytic and sedative agents.
Also presented are processes and intermediates in the production of the above pyrimido[4,5-d][2]benzazepines.

REFERENCES:
patent: 4427589 (1984-01-01), Fryer et al.
Fryer et al, Chem. Abst. vol. 97, 1982, p. 613, 6316g.
Fryer et al, Chem. Abst. 100:139142z.

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