Pyrimidinyl-1,2-dithiole compounds and anti-bilharzia compositio

Details Pyrimidinyl-1,2-dithiole compounds and anti-bilharzia compositio Pyrimidinyl-1,2-dithiole compounds and anti-bilharzia compositio

1977-11-17

1979-03-20

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544242, C07D23906, A61K 31505

Patent

active

041454235

ABSTRACT:
1,2-Dithiole derivatives of the formula: ##STR1## wherein Het represents a pyridazin-3-yl radical, or a pyrimidin-2-yl, -4-yl or -5-yl radical, each such radical being optionally substituted by a halogen atom or by an alkyl radical of 1 through 4 carbon atoms, an alkoxy radical of 1 through 4 carbon atoms, the mercapto radical, an alkylthio radical of 1 through 4 carbon atoms or a dialkylamino group having 1 through 4 carbon atoms in each alkyl radical, are new compounds useful in the treatment of bilharziasis and amoebiasis.

REFERENCES:
Bottcher et al., Chem. Ber. vol. 84, pp. 458-463 (1951).
Le Grand et al., Bull. Soc. Chim. (France) pp. 79-83 (1955).
The Chemistry of Heterocyclic Compounds, vol. 21, 1st Part, pp. 382-384 (1966).

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