Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1974-12-09
1976-12-07
Rizzo, Nicholas S.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
2602564N, 2602565R, 2602855, 424251, C07D45702
Patent
active
039962288
ABSTRACT:
Pyrimidinoaminoethyl ergoline derivatives of the formula: ##STR1## wherein R is hydrogen or methyl; R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, alkyl having 1 to 3 carbon atoms, methoxy and phenyl;
R.sub.3 is hydrogen, halogen, alkyl and alkoxy each having 1 to 3 carbon atoms, phenyl, nitro, amino, cyano, acylamino, carboxamido and carbalkoxy each having 1 to 3 carbon atoms, trifluoromethyl or --SO.sub.2 --Y wherein Y is hydroxyl, amino or methyl and R.sub.4 is hydrogen or methoxy are prepared by reacting an ergoline derivative of formula III and a 2-aminopyrimidine anion of formula II ##STR2##
REFERENCES:
patent: 3228943 (1966-01-01), Bernardi et al.
patent: 3238099 (1966-03-01), Zimmermann
patent: 3377351 (1968-04-01), Haack et al.
patent: 3499898 (1970-03-01), VON Bebenburg et al.
patent: 3646046 (1972-02-01), Arcamone et al.
Morrison et al.; Organic Chemistry 2nd Edition; (1969) p. 748.
Arcari Giuliana
Bernardi Luigi
Bosisio Germano
Glasser Alfredo
Temperilli Aldemio
Rizzo Nicholas S.
Societa Farmaceutici Italia S.p.A.
Vaughn Mary C.
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