Pyrimidines substituted by nitrogen-containing heterocyclic ring

Details Pyrimidines substituted by nitrogen-containing heterocyclic ring Pyrimidines substituted by nitrogen-containing heterocyclic ring

1984-02-24

1985-08-20

Raymond, Richard I.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 60, 544122, 544295, 544315, 544317, 544326, C07D40504, C07D41304, C07D41704

Patent

active

045365792

ABSTRACT:
1,2,4-Triazolo[4,3-c]pyrimidines substituted at the 5 or 7 position through a nitrogen atom which is part of a heterocyclic ring have been found to have potent bronchodilator activity and to be useful synthetic intermediates in the preparation of 1,2,4-triazolo[1,5-c]pyrimidines. Methods for inducing bronchodilation, pharmaceutical compositions, and synthetic processes and intermediates are also described.

REFERENCES:
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patent: 3053844 (1962-09-01), Miller et al.
patent: 4269980 (1981-05-01), Hardy et al.
Miller and Rose, x-Triazolopyrimidines, Part I, Synthesis as Potential Therapeutic Agents, J. Chem. Soc., 1963, 5642.
G. W. Miller et al., J. Chem. Soc., 1965, 3357.
Temple et al., J. Org. Chem., 1967, 33, 530.
D. J. Brown et al., Aust. J. Chem., 1978, 31, 2505.
D. J. Brown et al., Aust. J. Chem., 1979, 32, 1585.
W. J. Broadbent et al., J. Chem. Soc., 1965, 3369.
Shiho et al., Yakagaku Zasshi, 1956, 76, 804.

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