Pyrimidines linked to a quencher

Details Pyrimidines linked to a quencher Pyrimidines linked to a quencher

1998-06-10

2000-09-12

Powers, Fiona T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Azo

536 2532, C07H 2100

Patent

active

061179868

ABSTRACT:
Compounds are described comprising pyrimidines substituted at the C-5 position with a linker and quencher. These compounds when incorporated into hairpin oligonucleotides quench the fluorescence of fluorophores linked to the 5'-terminus of the oligonucleotide. These nucleotide-quencher compounds are also easy to incorporate into oligonucleotides using conventional, automated, oligonucleotide synthetic techniques.

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