Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-09-24
2008-09-02
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S256000, C544S323000, C544S324000, C544S326000, C544S328000, C544S329000
Reexamination Certificate
active
07419984
ABSTRACT:
The invention relates to pyrimidines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor-cells.
REFERENCES:
patent: 2691655 (1954-10-01), Hitchings et al.
patent: 3119823 (1964-01-01), Shapiro
patent: 3933814 (1976-01-01), Haberkorn et al.
patent: 3948893 (1976-04-01), Aichinger et al.
patent: 3966725 (1976-06-01), Reisdorff et al.
patent: 4219552 (1980-08-01), Haberkorn et al.
patent: 4499269 (1985-02-01), Bennion et al.
patent: 5102927 (1992-04-01), Rody et al.
patent: 5260362 (1993-11-01), Rody et al.
patent: 5545836 (1996-08-01), Reinehr et al.
patent: 5702717 (1997-12-01), Cha et al.
patent: 5856331 (1999-01-01), Bursten
patent: 6004985 (1999-12-01), Kochanny et al.
patent: 6150360 (2000-11-01), Daeyaert et al.
patent: 6150362 (2000-11-01), Henkin et al.
patent: 6150382 (2000-11-01), Kochanny et al.
patent: 6166014 (2000-12-01), Kochanny et al.
patent: 6193960 (2001-02-01), Metzger et al.
patent: 6288228 (2001-09-01), Henkin et al.
patent: 1200314 (1965-09-01), None
patent: 2226474 (1973-02-01), None
patent: 525 262 (1993-02-01), None
patent: 1321624 (1963-03-01), None
patent: 48-28486 (1973-04-01), None
patent: 49-69688 (1974-07-01), None
patent: 274102 (1970-04-01), None
patent: WO 91/11465 (1991-08-01), None
patent: WO 00/25780 (2000-05-01), None
patent: WO 01/25220 (2001-04-01), None
patent: WO 02/12198 (2002-02-01), None
patent: WO 02/36578 (2002-05-01), None
patent: WO 02/36586 (2002-05-01), None
Britten and Kohne, “Repeated Sequences in DNA,”Science 161(3841): 529-540, Aug. 9, 1968.
Brodskii et al., “The mechanism underlying the action of secondary aromatic amine- type antioxidants and their ethers on the radiation oxidation of N-butylpropionamide and polycaproamide,”Chemical Abstracts, Accession No. 69:3284, 1968.
Budesinsky et al., “Substituted 2,4-diamino-6-phenyl-1,3,5-triazines,”Chemical Abstracts, Accession No. 97:6328, 1982.
Burmistrov et al., “6-Amino-4-arylamino-2-(o-hydroxyphenyl) triazines,”Chemical Abstracts, Accession No. 61:47941, 1964.
Bursten et al., “Interleukin-1 Rapidly Stimulates Lysophosphatidate Acyltransferase and Phosphatidate Phosphohydrolase Activities in Human Mesangial Cells,”Journal of Biological Chemistry 266(31): 20732-20743, Nov. 5, 1991.
Bursten et al., “Lipid A activation of glomerular mesangial cells: mimicry of the bioactive lipid, phosphatidic acid,”American Journal of Physiology 262(2): C328-C338, Feb. 1992.
Chen, C. et al., “A Convenient Synthetic Method for Trisubstituted s-Triazines,”Chemical Abstracts, Accession No. 124:146076, 1995.
Eberhardt et al., “Human Lysophosphatidic Acid Acyltransferase,”Journal of Biological Chemistry 272(32): 20299-20305, Aug. 8, 1997.
Elkafrawy, A.F. et al., “Synthesis and reactions of some 4-aryl-2-benzylthio-1, 6-dihydro-6-thiono-1,3,5-triazines,”Chemical Abstracts, Accession No. 115:279963, 1991.
English, D., “Phosphatidic acid: A lipid messenger involved in intracellular and extracellular signaling,”Cell Signal 8(5): 341-347, 1996.
Fong and Engleman, “Dendritic Cells in Cancer Immunotherapy,”Annual Review of Immunology 18: 245-273, 2000.
Hoess and Abremski, “The Cre-loxRecombination System,”Nucleic Acids and Molecular Biology 4: 99-109, 1990.
Imamura et al, “Induction of in vitro tumor cell invasion of cellular monolayers by lysophosphatidic acid or phospholipase D,”Biochemical and Biophysical Research Communications 193(2): 497-503, Jun. 15, 1993.
Kester, M., “Platelet-Activating Factor Stimulates Phosphatidic Acid Formation in Cultured Rat Mesangial Cells: Roles of Phospholipase D, Diglyceride Kinase, and De Novo Phospholipid Synthesis,”Journal of Cellular Physiology 156: 317-325, 1993.
Köhler and Milstein, “Continuous cultures of fused cells secreting antibody of predefined specificity,”Nature 256(5517): 495-497, Aug. 7, 1975.
Kume and Shimizu, “cDNA Cloning and Expression of Murine 1-Acyl-sn-glycerol-3-phosphate Acyltransferase,”Biochemical and Biophysical Research Communications 237(3): 663-666, Aug. 28, 1997.
Leung et al., “Molecular Cloning of Two Alternatively Spliced Forms of Human Phosphatidic Acid Phosphatase cDNAs that Are Differentially Expressed in Normal and Tumor Cells,”DNA and Cell Biology 17(4): 377-385, Apr. 1998.
Losman et al., “Baboon anti-idiotype antibodies mimic a carcinoembryonic antigen epitope,”Int. J. Cancer 46(2): 310-314, Aug. 15, 1990.
Martin et al., “Increased concentrations of phosphatidate, diacylglycerol and ceramide inras- and tyrosine kinase (fps)-transformed fibroblasts,”Oncogene 14(13):1571-1580, Apr. 3, 1997.
Michalik, M. et al., “Synthesis of nitrogen-containing heterocycles,”Chemical Abstracts, Accession No. 79:18680, 1973.
Miller and Rosman, “Improved Retroviral Vectors for Gene Transfer and Expression,”BioTechniques 7(9): 980-EOA, Oct. 1989.
Moolenaar, W.H., “Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger,”Journal of Biological Chemistry 270(22): 12949-12952, Jun. 2, 1995.
Moussa, G.E.M. et al., “Some reactions on 4-aryl-2-substituted amino-1,6-dihydro-6-thioxo-1,3,5 triazines,”Chemical Abstracts, Accession No. 113:59112, 1990.
Orlandi et al., “Cloning immunoglobulin variable domains for expression by the polymerase chain reaction,”Proc. Natl. Acad. Sci. USA 86(10): 3833-3837, May 1989.
Pitts et al., “Rapid Synthesis of Triazine Inhibitors of Inosine Monophosphate Dehydrogenase,”Bioorganic&Medicinal Chemistry Letters 12: 2137-2140, 2002.
Rizzo et al., “The Recruitment of Raf-1 to Membranes Is Mediated by Direct Interaction with Phosphatidic Acid and Is Independent of Association with Ras,”Journal of Biological Chemistry 275(31): 23911-23918, Aug. 4, 2000.
Sauer, B., “Inducible Gene Targeting in Mice Using the Cre/loxSystem,”Methods: A Companion to Methods in Enzymology 14(4): 381-392, Apr. 1998.
Schreurs et al., “Dendritic Cell-Based Vaccines: From Mouse Models to Clinical Cancer Immunotherapy,”Critical Reviews in Oncogenesis 11(1): 1-17, 2000.
Shapiro, S.L. et al., “Guanamines. VIII. 6-(Substituted-phenyl) guanamines,”Chemical Abstracts, Accession No. 56:60602, 1962.
Sharp et al., “Viral DNA in Transformed Cells. I. A Study of the Sequences of Adenovirus 2 DNA in a Line of Transformed Rat Cells Using Specific Fragments of the Viral Genome,”J. Mol. Biol. 86(4): 709-726, Jul. 15, 1974.
Sluka et al., “2,4-diamino-6-phenyl-1,3,5-triazines,”Collection Czechoslov. Chem. Commun. 43: 1639-1646, 1978.
Stamps et al., “A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases,”Biochemical Journal 326:455-461, Sep. 1, 1997.
Sutton, W.D., “A crude nuclease preparation suitable for use in DNA reassociation experiments,”Biochimica et Biophysica Acta 240(4): 522-531, Jul. 29, 1971.
West et al., “Cloning and Expression of Two Human Lysophosphatidic Acid Acyltransferase cDNAs That Enhance Cytokine-Induced Signaling Responses in Cells,”DNA and Cell Biology 16(6): 691-701, Jun. 1997.
Wetmur and Davidson, “Kinetics of Renaturation of DNA,”Journal of Molecular Biology 31(3): 349-370, Feb. 14, 1968.
Xu et al, “Lysophospholipids activate ovarian and breast cancer cells,”Biochemical Journal 309: 933-940, Aug. 1, 1995.
Yuki, Y. et al., “Preparation of amino-s-triazines with amino-or nitrophenyl groups,”Chemical Abstracts, Accession No. 75:151765, 1971.
Bhatt Rama
Gong Baoqing
Hong Feng
Jenkins Scott A
Klein J Peter
Cell Therapeutics Inc.
Rao Deepak
LandOfFree
Pyrimidines and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pyrimidines and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrimidines and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3974288