Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-06-05
1999-01-12
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544295, 544301, 544311, C07D23904, C07D23910, A61K 31505
Patent
active
058590145
ABSTRACT:
Compounds of Formula I: ##STR1## where R.sup.5 is a group selected from Formulae (a), (b), (c) and (d): ##STR2## and the pharmaceutically acceptable salts and N-oxides thereof, are .alpha..sub.1 -adrenergic receptor antagonists useful for the treatment of diseases involving directly or indirectly an obstruction of the lower urinary tract, such as benign prostatic hyperplasia.
REFERENCES:
patent: 4216216 (1980-08-01), Weber et al.
patent: 4931444 (1990-06-01), Van Wauwe et al.
patent: 5075308 (1991-12-01), Ishikawa et al.
Derwent WPI, Abstract No. 91-099173 (abstract of Japanese Patent Kokai No. 44,379/1991--Yamasa Shoyu K.K.) Derwent Publications Ltd., London, England, 1991; and Chemical Abstracts, Abstract No. 115:159177c, Chemical Abstracts Service, Columbus, Ohio, 1991.
Patent Abstracts of Japan, Abstract No. 14:458 (C-0766) (abstract of Japanese Patent Kokai No. 184,667/1990--Meiji Seika Kaisha Ltd.), Tokyo, Japan, 1990; and Chemical Abstracts, Abstract No. 114:12226p, Chemical Abstracts Service, Columbus, Ohio, 1990.
G. Romeo et al., "Heterocyclic systems containing the pyrimido-2,4-dione ring as selective ligands for the .alpha..sub.1 -adrenoceptors", II Farmaco, 50(6), 471-477 (1995).
J.L. Mokrosz et al., "A search for new trazodone-like antidepressants: synthesis and preliminary binding studies", Arch. Phar. (Weinheim), 328, 623-625 (1995).
Chemical Abstracts, Abstract No. 122:282093u (abstract of R. Villalobos-Molina et al., "The 5-HT.sub.2 receptor antagonist, pelanserin, inhibits .alpha..sub.1 -adrenoceptor-mediated vasoconstriction in vitro", Eur. J. Pharmacol., 277(2/3), 181-185 (1995)), Chemical Abstracts Service, Columbus, Ohio, 1995.
Chemical Abstracts, Abstract No. 106:188841j (abstract of J. Longmore et al., "Antagonism of phenylephrine-evoked sweating by trazodone and amitryptyline in humans in vivo", Br. J. Clin. Pharmacol., 23(2), 245-246 (1987)), Chemical Abstracts Service, Columbus, Ohio, 1987.
Bantle Gary W.
Elworthy Todd R.
Guzman Angel
Jaime-Figueroa Saul
Lopez-Tapia Francisco J.
Rao Deepak R.
Shah Mukund J.
Syntex (U.S.A.) Inc.
LandOfFree
Pyrimidinedione, pyrimidinetrione, triazinedione and tetrahydroq does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pyrimidinedione, pyrimidinetrione, triazinedione and tetrahydroq, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrimidinedione, pyrimidinetrione, triazinedione and tetrahydroq will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1516249