Pyrimidineamide derivatives and the use thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C544S324000

Reexamination Certificate

active

07655669

ABSTRACT:
The invention relates to novel substituted N-(3-benzoylaminophenyl)-4-pyridyl-2-pyrimidinamine derivatives, processes for the preparation thereof, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, especially a neoplastic disease, and a method for the treatment of such a disease.

REFERENCES:
patent: 5215989 (1993-06-01), Baldwin et al.
patent: 5516775 (1996-05-01), Zimmermann et al.
patent: 5521184 (1996-05-01), Zimmermann
patent: 0 233 461 (1987-08-01), None
patent: 0 564 409 (1993-10-01), None
patent: 0 588 762 (1994-03-01), None
patent: 2 369 359 (2002-05-01), None
patent: 0 564 409 (1993-10-01), None
patent: WO 95/09847 (1995-04-01), None
patent: WO 95/09852 (1995-04-01), None
patent: WO 01/47507 (2001-07-01), None
patent: WO 01/64200 (2001-09-01), None
patent: 02 22597 (2002-03-01), None
patent: WO 02/22597 (2002-03-01), None
patent: 02 93164 (2002-11-01), None
patent: WO 02/093164 (2002-11-01), None
Traxler, Protein Tyrosine Kinase inhibitors in Cancer treatment, Expert Opinion on Therapeutic Patents, 7(6), pp. 571-588, 1997.
Yano et al., Medline Abstract (Clinical Cancer Research, vol. 6, Issue 3, pp. 957-965), Mar. 2000.
Cressey et al., Medline Abstract (BMC Cancer, vol. 5, p. 128) Oct. 2005.
Simone, Onclogy: Introduction, Cecil Textbook of Medicine, 20thEdition, vol. 1, pp. 1004-1010, 1996.
Buchdunger et al., “Selective Inhibition of the Platelet-Derived Growth Factor Signal Transduction Pathway by a Protein-Tyrosine Kinase Inhibitor of the 2-Phenylaminopyrimidine Class”,Proc Natl Acad Sci USA, vol. 92, No. 7, pp. 2558-2562 (1995).
Buchdunger et al., “Inhibition of the Abl Protein-Tyrosine Kinase in Vitro and in Vivo by a 2-Phenylaminopyrimidine Derivative”,Cancer Res, vol. 56, No. 1, pp. 100-104 (1996).
Carroll et al., “CGP 57148, A Tyrosine Kinase Inhibitor, Inhibits the Growth of Cells Expressing BCR-ABL, TEL-ABL, and TEL-PDGFR Fusion Proteins”,Blood, vol. 90, No. 12, pp. 4947-4952 (1997).
Druker et al., “Effects of a Selective Inhibitor of the Abl Tyrosine Kinase on the Growth of Bcr-Abl Positive Cells”,Nat Med, vol. 2, No. 5, pp. 561-566 (1996).
Druker et al., “Selective Killing of Bcr-Abl Positive Cells with a Specific Inhibitor of the Abl Tyrosine Kinase”, Pezcoller Foundation Symposia,Cancer Genes, pp. 255-267 (1996).
Zimmermann et al., “Phenylamino-Pyrimidine (PAP) Derivatives: A New Class of Potent and Selective Inhibitors of Protein Kinase C (PKC)”,Arch Pharm Pharm Med Chem, vol. 329, No. 7, pp. 371-376 (1996).
Zimmermann et al., “Phenylamino-Pyrimidine (PAP)—Derivatives: A New Class of Potent and Highly Selective PDGF-Receptor Autophosphorylation Inhibitors”,Bioorg Med Chem Lett, vol. 6, No. 11, pp. 1221-1226 (1996).
Zimmermann et al., “Potent and Selective Inhibitors of the Abl-Kinase: Phenylamino-Pyrimidine (PAP) Derivatives”,Bioorg Med Chem Lett, vol. 7, No. 2, pp. 187-192 (1997).

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