Pyrimidine to pyrimidine transformation process

Details Pyrimidine to pyrimidine transformation process Pyrimidine to pyrimidine transformation process

1977-03-29

1979-10-16

Rollins, Alton D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 424251, 544309, 544314, 544320, C07D23946, C07D23956, C07D40704, C07H 1906

Patent

active

041714296

ABSTRACT:
There is provided a novel process for pyrimidine to pyrimidine transformations by the displacement of the 1,2,3-portion of a pyrimidine by a 1,3-ambident nucleophile. The novel process requires that the 1 and 3 nitrogens of the pyrimidine moiety be substituted. The novel process makes available, inter alia, novel uracils, simple methods of radioisotopically labeling pyrimidine nuclei, a simple and inexpensive method of preparing the important antiviral and antileukemic material pseudoisocytidine and its new active analog 2'-deoxypseudoisocytidine.

REFERENCES:
shugar et al., Biochem. Biophys. Acta., vol. 9, pp. 199-215 (1952).

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